Position
| Chromosome | chr5 |
| Start | 18409503 |
| End | 18499883 |
| Strand | - |
view in Gbrowse: chr5:18409503..18499883
Most similar sequence in NCBI nr database
| Accession | Description | E-value | Score |
|---|
| NP_001091842.2 | nicotinic acetylcholine receptor subunit alpha 6 isoform 1 precursor | 0.0 | 1030 |
ORF sequence (1506 bp)
ATGGTGCCGATCCTGGCGGCCTTCGCGCTGCTGGCTCTGCTGCCCGTGTCGGAGCAAGGTCCACACGAAAAACGTCTGCTGAACGCCCTGCTGGCGTCTTACAACACCCTGGAGCGTCCTGTGGCCAATGAGAGCGAGCCCCTAGAGGTACGCTTTGGGCTGACACTGCAACAAATCATAGATGTGGATGAGAAAAATCAAATCCTGACCACGAACGTCTGGCTAAACTTGGAATGGAATGACTACAACCTAAGGTGGAACGAGAGCGAGTACGGAGGCGTCAAGGACTTAAGGATAACACCGAACAAACTTTGGAAACCAGACGTTCTCATGTACAACAGTGCTGACGAGGGTTTTGACGGGACATACCAGACGAACGTGGTGGTCAGAAACAACGGCAGTTGTCTGTACGTGCCCCCGGGCATTTTCAAGAGCACATGCAAGATAGATATCACGTGGTTTCCCTTCGACGACCAACACTGTGATATGAAGTTTGGTAGCTGGACATATGATGGCAATCAGCTGGACCTCATCTTGAAGGACGAAGCCGGTGGCGACCTATCAGATTTCATCACGAATGGAGAATGGTACTTAATAGGAATGCCGGGCAAAAAGAACACAATTACATACGCTTGCTGCCCAGAGCCGTACGTGGACGTCACCTTCACCATCATGATCAGGAGGAGAACGCTGTACTACTTCTTCAATCTCATCGTGCCGTGCGTTCTGATATCCTCAATGGCGCTACTAGGCTTCACGCTACCACCAGATTCTGGGGAGAAATTGACACTCGGAGTCACTATTCTACTGTCGCTGACGGTGTTTCTCAATCTGGTGGCAGAAACTCTGCCGCAGGTGTCCGATGCTATCCCCTTGTTAGGTACATATTTCAACTGTATTATGTTCATGGTGGCCTCGTCTGTGGTGCTCACCGTTGTGGTGTTGAACTACCATCATCGAACGGCTGACATCCATGAGATGCCACAATGGATAAAGACTGTGTTCCTCCAATGGCTGCCCTGGATTCTGCGTATGTCCAGGCCGGGTAAGAAGATCACGAGGAAGACCATCATGATGTCCAACAGGATGCGAGAGTTGGAGCTAAAAGAGCGTTCGTCTAAGTCGCTGTTAGCCAACGTGCTGGATATAGACGACGACTTTAGACATGCCCCGCCCCCGCCCAACAGTACTGCTTCTACAGGCAACTTGGGGCCTGGTTGCTCAATATTTAGAACGGACTTTCGGCGTTCGTTCGTCCGCCCTTCGACGATGGAGGACGTGGGCGGAGGGCTCAGTAGCCACCACAGGGAGCTGCATCTCATCCTGCGCGAACTCCAGTTCATCACAGCCAGGATGAAGAAGGCCGATGAGGAGGCCGAGCTGATCAGCGACTGGAAATTCGCTGCAATGGTAGTGGACAGGTTTTGCTTGTTCGTGTTCACGTTGTTCACGATAATAGCGACGGTGGCCGTGCTGTTGTCGGCGCCGCATATCATCGTGCAGTGA
Protein sequence (501 aa)
MVPILAAFALLALLPVSEQGPHEKRLLNALLASYNTLERPVANESEPLEVRFGLTLQQIIDVDEKNQILTTNVWLNLEWNDYNLRWNESEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQHCDMKFGSWTYDGNQLDLILKDEAGGDLSDFITNGEWYLIGMPGKKNTITYACCPEPYVDVTFTIMIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPQWIKTVFLQWLPWILRMSRPGKKITRKTIMMSNRMRELELKERSSKSLLANVLDIDDDFRHAPPPPNSTASTGNLGPGCSIFRTDFRRSFVRPSTMEDVGGGLSSHHRELHLILRELQFITARMKKADEEAELISDWKFAAMVVDRFCLFVFTLFTIIATVAVLLSAPHIIVQ
Domains and motifs
| Database | ID | Description | Start | End | Evalue | InterPro ID |
|---|
| Gene3D | 2.70.170.10 | - |
16 | 235 | 1.5e-92 |
IPR036734 |
| PANTHER | PTHR18945 | - |
20 | 499 | 7.4e-249 |
IPR006201 |
| PANTHER | PTHR18945:SF825 | - |
20 | 499 | 7.4e-249 |
- |
| TIGRFAM | TIGR00860 | LIC: cation transporter family protein |
20 | 494 | 1.9e-122 |
IPR006201 |
| SUPERFAMILY | SSF63712 | - |
22 | 229 | 1.7e-73 |
IPR036734 |
| Pfam | PF02931 | Neurotransmitter-gated ion-channel ligand binding domain |
23 | 230 | 2.4e-75 |
IPR006202 |
| CDD | cd18997 | LGIC_ECD_nAChR |
48 | 229 | 3.5e-118 |
- |
| ProSitePatterns | PS00236 | Neurotransmitter-gated ion-channels signature. |
147 | 161 | - |
IPR018000 |
| SUPERFAMILY | SSF90112 | - |
230 | 500 | 3.5e-77 |
IPR036719 |
| CDD | cd19051 | LGIC_TM_cation |
231 | 303 | 2.3e-37 |
- |
| Gene3D | 1.20.58.390 | - |
236 | 348 | 4.8e-43 |
- |
| Pfam | PF02932 | Neurotransmitter-gated ion-channel transmembrane region |
237 | 491 | 5.1e-58 |
IPR006029 |
| Gene3D | 1.20.58.390 | - |
427 | 501 | 5.4e-13 |
- |
InterPro assignment
| InterPro ID | InterPro description |
|---|
| IPR006029 | Neurotransmitter-gated ion-channel transmembrane domain |
| IPR006201 | Neurotransmitter-gated ion-channel |
| IPR006202 | Neurotransmitter-gated ion-channel ligand-binding domain |
| IPR018000 | Neurotransmitter-gated ion-channel, conserved site |
| IPR036719 | Neurotransmitter-gated ion-channel transmembrane domain superfamily |
| IPR036734 | Neurotransmitter-gated ion-channel ligand-binding domain superfamily |
Gene ontology (GO) assignment
| GO category | GO ID | GO description |
|---|
| molecular function | GO:0004888 | transmembrane signaling receptor activity |
| molecular function | GO:0005216 | ion channel activity |
| molecular function | GO:0005230 | extracellular ligand-gated ion channel activity |
| biological process | GO:0006811 | ion transport |
| cellular component | GO:0016021 | integral component of membrane |
| biological process | GO:0034220 | ion transmembrane transport |