Position
| Chromosome | chr7 |
| Start | 12666078 |
| End | 12688036 |
| Strand | + |
view in Gbrowse: chr7:12666078..12688036
Most similar sequence in NCBI nr database
| Accession | Description | E-value | Score |
|---|
| NP_001275941.1 | glutamate-gated chloride channel-like precursor | 0.0 | 929 |
ORF sequence (1341 bp)
ATGGAATTCCCTCGGCGGCCATGTGCCCTGCTTGTTCTGATACTATCTTACTTCACACAATTAGCAATATGTATGAATTCGGGCAAGATAAACTTCAGGGAGAAGGAGAAGCAGATCTTGGACCAGATCCTCGGGCCGGGGCGGTACGACGCCCGCATCAGACCGTCAGGCATCAACGGAACTGATGGGCCAGCGGTAGTCAGCGTCAATATATTTGTCAGGAGTATATCAAAGATCGATGACGTCACAATGGAATACTCTGTGCAACTCACGTTCAGAGAACAATGGCTGGACGAGAGACTGAAGTTTAACAATTTAGGAGGTCGTCTCAAATACTTGACCCTGACCGAGGCCAACAGGGTTTGGATGCCCGACCTGTTCTTCTCGAACGAGAAGGAAGGCCACTTTCACAACATCATCATGCCCAACGTGTACATCAGGATCTTTCCGAACGGGACCGTCCTGTACAGCATCCGTATCTCTCTCACTCTGTCGTGTCCCATGAACCTCAAGCTGTACCCGCTGGACAAGCAGACCTGCTCCTTGAGGATGGCCAGCTACGGCTGGACCACGGACGACCTCGTGTTCTTGTGGAAGGAAGGCGATCCTGTCCAGGTCGTGAAGAATCTCCATCTCCCAAGATTCACTCTGGAGAAGTTCCGCACCGATTATTGCAACAGCAAGACTAATACCGGCGAATACAGCTGCCTGAAGGTAGACCTGCTGTTCAAACGCGAGTTCAGCTACTACCTCATCCAGATCTACATCCCGTGCTGCATGCTCGTCATCGTCTCCTGGGTCTCCTTCTGGCTCGACCAGGGAGCAGTCCCGGCCCGAGTCTCTCTTGGCGTGACAACCCTGCTGACAATGGCCACTCAGTCATCAGGCATCAACGCCTCCCTACCGCCGGTATCGTATACAAAAGCCATCGACGTCTGGACGGGAGTCTGTCTGACCTTCGTCTTTGGAGCTCTACTGGAGTTCGCCCTCGTCAATTATGCGTCTCGCTCTGACATGCACAGAGAGAACATGAAAAAAACGAGACGGGAGATGGAGGCCGCCAGTATGGACGCTGCCTCGGATCTCTTGGACACGGATAGCAACGCCACCTTCGCTATGAAACCTCTGGTCCGCGGTGGCGTGGACACTAAGATGCGGCAGTGCGAGATCCACATCAGCCAGCCCAGGAAGAACTGCTGCCGGCTCTGGATGTCCAAGTTTCCCACGCGCTCCAAGAGGATCGACGTCATCTCCAGGATCACGTTTCCTCTTGTTTTCGCCATTTTCAATTTGGCTTACTGGTCAACATATTTGTTTCGCGACGAGGAGGAAGAGAAGTGA
Protein sequence (446 aa)
MEFPRRPCALLVLILSYFTQLAICMNSGKINFREKEKQILDQILGPGRYDARIRPSGINGTDGPAVVSVNIFVRSISKIDDVTMEYSVQLTFREQWLDERLKFNNLGGRLKYLTLTEANRVWMPDLFFSNEKEGHFHNIIMPNVYIRIFPNGTVLYSIRISLTLSCPMNLKLYPLDKQTCSLRMASYGWTTDDLVFLWKEGDPVQVVKNLHLPRFTLEKFRTDYCNSKTNTGEYSCLKVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWLDQGAVPARVSLGVTTLLTMATQSSGINASLPPVSYTKAIDVWTGVCLTFVFGALLEFALVNYASRSDMHRENMKKTRREMEAASMDAASDLLDTDSNATFAMKPLVRGGVDTKMRQCEIHISQPRKNCCRLWMSKFPTRSKRIDVISRITFPLVFAIFNLAYWSTYLFRDEEEEK
Domains and motifs
| Database | ID | Description | Start | End | Evalue | InterPro ID |
|---|
| TIGRFAM | TIGR00860 | LIC: cation transporter family protein |
12 | 437 | 0.0 |
IPR006201 |
| Gene3D | 2.70.170.10 | - |
29 | 244 | 1.1e-74 |
IPR036734 |
| SUPERFAMILY | SSF63712 | - |
35 | 246 | 4.0e-54 |
IPR036734 |
| Pfam | PF02931 | Neurotransmitter-gated ion-channel ligand binding domain |
36 | 246 | 3.1e-48 |
IPR006202 |
| PANTHER | PTHR18945 | - |
37 | 438 | 5.0e-126 |
IPR006201 |
| PANTHER | PTHR18945:SF754 | - |
37 | 438 | 5.0e-126 |
IPR015680 |
| CDD | cd18993 | LGIC_ECD_GluCl |
64 | 246 | 4.4e-129 |
- |
| ProSitePatterns | PS00236 | Neurotransmitter-gated ion-channels signature. |
166 | 180 | - |
IPR018000 |
| CDD | cd19062 | LGIC_TM_GluCl |
249 | 437 | 2.6e-61 |
- |
| SUPERFAMILY | SSF90112 | - |
249 | 439 | 3.0e-50 |
IPR036719 |
| Pfam | PF02932 | Neurotransmitter-gated ion-channel transmembrane region |
254 | 353 | 8.8e-29 |
IPR006029 |
InterPro assignment
| InterPro ID | InterPro description |
|---|
| IPR006029 | Neurotransmitter-gated ion-channel transmembrane domain |
| IPR006201 | Neurotransmitter-gated ion-channel |
| IPR006202 | Neurotransmitter-gated ion-channel ligand-binding domain |
| IPR015680 | Glutamate-Gated Chloride Channel |
| IPR018000 | Neurotransmitter-gated ion-channel, conserved site |
| IPR036719 | Neurotransmitter-gated ion-channel transmembrane domain superfamily |
| IPR036734 | Neurotransmitter-gated ion-channel ligand-binding domain superfamily |
Gene ontology (GO) assignment
| GO category | GO ID | GO description |
|---|
| molecular function | GO:0004888 | transmembrane signaling receptor activity |
| molecular function | GO:0005216 | ion channel activity |
| molecular function | GO:0005230 | extracellular ligand-gated ion channel activity |
| biological process | GO:0006811 | ion transport |
| cellular component | GO:0016021 | integral component of membrane |
| biological process | GO:0034220 | ion transmembrane transport |